Primary Costal Bone Xanthoma
Article Sidebar
Main Article Content
Abstract
Primary bone xanthoma is an exceptionally infrequent clinical entity. It predominantly affects young men, with a higher occurrence in flat bones of the axial skeleton. This pathology can present in an
isolated (primary) form or as secondary, associated with endocrinological and metabolic disorders such as hyperlipidemia. It is always necessary to investigate and rule out the secondary cause to certify normolipidemia. The therapeutic approach should be tailored to the lesion characteristics, location, and neighboring structures’ affectation.
We present the case of a female patient with no significant history who had an incidental finding of a costal lytic lesion on computed tomography. Due to the risk of fracture and the inability to rule out malignancy, we performed a resection of the body of the fifth right rib, guided by video-assisted thoracoscopic surgery. The histopathological study reported a medullary cavity with infiltration of foamy macrophages and numerous cholesterol crystals, confirming the diagnosis of bone xanthoma.
Downloads
Article Details
Section
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
How to Cite
References
Bertoni F, Unni KK, McLeod RA, et al. Xanthoma of bone. Am J Clin Pathol. 1988;90(4):377-384. https://doi.org/10.1093/ajcp/90.4.377.
Marqués Mateo M, Puche Torres M, Miragall Alba L, et al. Primary mandibular bone xanthoma. A case report. Int J Oral Maxillofac Surg. 2004;33(8):806-807. https://doi.org/10.1016/j.ijom.2003.12.006.
Ali S, Fedenko A, Syed AB, et al. Bilateral primary xanthoma of the humeri with pathologic fractures: a case report. World J Radiol. 2013;5(9):345-348. https://doi.org/10.4329/wjr.v5.i9.345.
Alden KJ, McCarthy EF, Weber KL. Xanthoma of bone: a report of three cases and review of the literature. Iowa Orthop J. 2008;28:58-64.
Ortega Hrescak MC, Jerez JM, Arévalo CM, et al. Xantoma intraóseo pelviano: reporte de un caso y revisión de la literatura. Rev Argent Radiol. 2014;78(3):161-167. https://doi.org/10.1016/j.rard.2014.07.005.
Huang CF, Cheng SN, Hung CH, et al. Xanthoma of bone in a normolipidemic child: report of one case. Acta Paediatr Taiwan. 2000;41(3):158-160.
Asano K, Sato J, Matsuda N, et al. A rare case of primary bone xanthoma of the clivus. Brain Tumor Pathol. 2012;29(2):123-128. https://doi.org/10.1007/s10014-011-0073-x.
Yokoyama E, Ito J, Tokiguchi S, et al. [A case of xanthoma of the skull]. Rinsho Hoshasen. 1990;35(9):1057-1060.
Ahmed G, Al Dosari M, El-Mahi M, et al. Primary xanthoma of calcaneus bone: case report. Int J Surg Case Rep. 2014;5(10):699-702. https://doi.org/10.1016/j.ijscr.2014.07.016.
Ocakcioglu I, Sayir F. Rib resection using a Gigli saw under thoracoscopic guidance. Wideochir Inne Tech Maloinwazyjne. 2019;14(1):126-132. https://doi.org/10.5114/wiitm.2018.77266.
Mottola E, Adotti F, Pernazza A, et al. Xanthoma of rib: a case report and review of the literature. https://doi.org/10.21203/rs.3.rs-1561164/v1.