Pancytopenia Associated with Risperidone Use: Case Report

Authors

  • Alvaro Vallejos Narváez Cátedra de Farmacología Clínica, Facultad de Medicina. Fundación Universitaria de Ciencias de la Salud. Bogotá, Colombia
  • Daniel Prieto Vargas Carrera Medicina. Fundación Universitaria de Ciencias de la Salud. Bogotá, Colombia
  • Sofía Correa Osorio Carrera Medicina. Fundación Universitaria de Ciencias de la Salud. Bogotá, Colombia
  • Paula Pinilla Amaya Carrera Medicina. Fundación Universitaria de Ciencias de la Salud. Bogotá, Colombia
  • Andrés Romero Burgos Carrera Medicina. Fundación Universitaria de Ciencias de la Salud. Bogotá, Colombia
  • Valeria Sánchez Vega Carrera Medicina. Fundación Universitaria de Ciencias de la Salud. Bogotá, Colombia
  • Hugo Aguilar Hernández Carrera Medicina. Fundación Universitaria de Ciencias de la Salud. Bogotá, Colombia
  • Roynner Hernández Sarmiento Carrera Medicina. Fundación Universitaria de Ciencias de la Salud. Bogotá, Colombia
  • Juan Parrado Arboleda Carrera Medicina. Fundación Universitaria de Ciencias de la Salud. Bogotá, Colombia

DOI:

https://doi.org/10.51987/revhospitalbaires.v44i2.329

Keywords:

Risperidone, pancytopenia, leukopenia, adverse drug reaction, case report

Abstract

85-year-old woman with multiple comorbidities: Chronic obstructive pulmonary disease and heart failure. Hospitalization one month ago for pulmonary thromboembolism managed with rivaroxaban 20 mg/day; mixed delirium and dementia treated with risperidone, initially 0.5 mg/day and then 1 mg/day upon discharge. Hospitalary readmission by urinary septic shock related to infection by Klebsiella Pneumoniae KPC, treated with ceftazidime/avibactam 2.5 gr every 8 hours Blood count (BC) on admission with 770 leukocytes/mm3, hemoglobin 6.3 gr/dl, hematocrit 18.9% and platelets 61,000/mm3. Risperidone was suspended and haloperidol was started, two units of red blood cells were transfused, showing improvement on fourth day, 1.840 leukocytes/mm3, 740 neutrophils/mm3, hemoglobin 9.8 gr/dl, hematocrit 29.3% and platelets 227,000/mm3. Causality of adverse drug reaction evaluated with the World Health Organization algorithm was classified as “possible”.

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Published

2024-06-28

Issue

Vol. 44 No. 2 (2024): Revista del Hospital Italiano de Buenos Aires

Section

Clinical case

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Copyright (c) 2024 Revista del Hospital Italiano de Buenos Aires

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How to Cite

1.
Vallejos Narváez A, Prieto Vargas D, Correa Osorio S, Pinilla Amaya P, Romero Burgos A, Sánchez Vega V, et al. Pancytopenia Associated with Risperidone Use: Case Report. Rev Hosp Ital B.Aires [Internet]. 2024 Jun. 28 [cited 2026 Aug. 21];44(2):e0000329. Available from: https://ojs.hospitalitaliano.org.ar/index.php/revistahi/article/view/329

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