Fisiopatología de la enterocolitis necrotizante (ECN)

Barra lateral del artículo

PDF
Publicado: 10-12-2011
DOI: https://doi.org/10.51987/Rev.Hosp.Ital.B.Aires.v31i4.955

Contenido principal del artículo

Carlos Alberto Fustiñana
Servicio de Neonatología. Hospital Italiano de Buenos Aires, Argentina

Resumen

.

Downloads

Download data is not yet available.

Detalles del artículo

Número

Vol. 31 Núm. 4 (2011): Revista del Hospital Italiano de Buenos Aires

Sección

Revisión
Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.

Cómo citar

1.
Fustiñana CA. Fisiopatología de la enterocolitis necrotizante (ECN). Rev Hosp Ital B.Aires [Internet]. 2011 Dec. 10 [cited 2026 Apr. 26];31(4):137-42. Available from: https://ojs.hospitalitaliano.org.ar/index.php/revistahi/article/view/955

Referencias

Neu J, Walker WA. Necrotizing enterocoli-tis. N Engl J Med. 2011;364(3):255-64 DOI: https://doi.org/10.1056/NEJMra1005408

Bortolin L, Boer M, Christiansen S, et al. [Effects of prenatal steroids in the de-velopment of necrotizing enterocolitis in Wistar rat neonates]. Arch Argent Pediatr. 2011;109(1):24-9.

Lin PW, Stoll BJ. Necrotising enterocolitis. Lancet. 2006;368(9543):1271-83. DOI: https://doi.org/10.1016/S0140-6736(06)69525-1

Guthrie SO, Gordon PV, Thomas V, et al. Necrotizing enterocolitis among neo-nates in the United States. J Perinatol. 2003;23(4):278-85. DOI: https://doi.org/10.1038/sj.jp.7210892

Berseth CL. Neonatal small intestinal mo-tility: motor responses to feeding in term and preterm infants. J Pediatr. 1990;117(5):777-82. DOI: https://doi.org/10.1016/S0022-3476(05)83343-8

Berseth CL, Ittmann PI. Antral and duode-nal motor responses to duodenal feeding in preterm and term infants. J Pediatr Gastroen-terol Nutr. 1992;14(2):182-6. DOI: https://doi.org/10.1002/j.1536-4801.1992.tb10522.x

al Tawil Y, Berseth CL. Gestational and postnatal maturation of duodenal motor re-sponses to intragastric feeding. J Pediatr. 1996;129(3):374-81. DOI: https://doi.org/10.1016/S0022-3476(96)70069-0

Sase M, Lee JJ, Ross MG, Buchmiller-Crair TL. Effect of hypoxia on fetal rab-bit gastrointestinal motility. J Surg Res. 2001;99(2):347-51 DOI: https://doi.org/10.1006/jsre.2001.6189

Neu J. The 'myth' of asphyxia and hypox-ia-ischemia as primary causes of necrotizing enterocolitis. Biol Neonate. 2005;87(2):97-8. DOI: https://doi.org/10.1159/000081898

Berseth CL, McCoy HH. Birth asphyxia alters neonatal intestinal motility in term neo-nates. Pediatrics. 1992;90(5):669-73. DOI: https://doi.org/10.1542/peds.90.5.669

Lebenthal A, Lebenthal E. The ontogeny of the small intestinal epithelium. JPEN J Par-enter Enteral Nutr. 1999;23(5 Suppl):S3-6. DOI: https://doi.org/10.1177/014860719902300502

Di Lorenzo M, Bass J, Krantis A. An in-traluminal model of necrotizing enterocolitis in the developing neonatal piglet. J Pediatr Surg. 1995;30(8):1138-42 DOI: https://doi.org/10.1016/0022-3468(95)90006-3

Nusrat A, Turner JR, Madara JL. Molecu-lar physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells. Am J Physiol Gastrointest Liver Physiol. 2000;279(5):G851-7. DOI: https://doi.org/10.1152/ajpgi.2000.279.5.G851

Liu Z, Li N, Neu J. Tight junctions, leaky intestines, and pediatric diseases. Acta Paedi-atr. 2005;94(4):386-93. DOI: https://doi.org/10.1111/j.1651-2227.2005.tb01904.x

Buisine MP, Devisme L, Savidge TC, Gespach C, Gosselin B, Porchet N, Aubert JP. Mucin gene expression in human embryonic and fetal intestine. Gut. 1998;43(4):519-24. DOI: https://doi.org/10.1136/gut.43.4.519

Otte JM, Kiehne K, Herzig KH. An-timicrobial peptides in innate immunity of the human intestine. J Gastroenterol. 2003;38(8):717-26 DOI: https://doi.org/10.1007/s00535-003-1136-5

Eckmann L. Defence molecules in in-testinal innate immunity against bacte-rial infections. Curr Opin Gastroenterol. 2005;21(2):147-51. DOI: https://doi.org/10.1097/01.mog.0000153311.97832.8c

Salzman NH, Polin RA, Harris MC, et al. Enteric defensin expression in necrotizing enterocolitis. Pediatr Res. 1998;44(1):20-6.

Upperman JS, Potoka D, Grishin A, et al. Mechanisms of nitric oxide-mediated intesti-nal barrier failure in necrotizing enterocolitis. Semin Pediatr Surg. 2005;14(3):159-66. DOI: https://doi.org/10.1053/j.sempedsurg.2005.05.004

Hackam DJ, Upperman JS, Grishin A, et al. Disordered enterocyte signalling and in-testinal barrier dysfunction in the pathogene-sis of necrotizing enterocolitis. Semin Pediatr Surg. 2005;14(1):49-57. DOI: https://doi.org/10.1053/j.sempedsurg.2004.10.025

Mshvildadze M, Neu J, Shuster J, et al. Intestinal microbial ecology in premature infants assessed with non-culture-based tech-niques. J Pediatr. 2010;156(1):20-5. DOI: https://doi.org/10.1016/j.jpeds.2009.06.063

Fusunyan RD, Nanthakumar NN, Balde-on ME, et al. Evidence for an innate immune response in the immature human intestine: toll-like receptors on fetal enterocytes. Pedi-atr Res. 2001;49(4):589-93 DOI: https://doi.org/10.1203/00006450-200104000-00023

Harris MC, D'Angio CT, Gallagher PR, et al. Cytokine elaboration in critically ill in-fants with bacterial sepsis, necrotizing enter-colitis, or sepsis syndrome: correlation with clinical parameters of inflammation and mor-tality. J Pediatr. 2005;147(4):462-8. DOI: https://doi.org/10.1016/j.jpeds.2005.04.037

Ganz T. Defensins: antimicrobial pep-tides of innate immunity. Nat Rev Immunol. 2003;3(9):710-20. DOI: https://doi.org/10.1038/nri1180

Neish AS. Molecular aspects of intestinal epithelial cell-bacterial interactions that de-termine the development of intestinal inflam-mation. Inflamm Bowel Dis. 2004;10(2):159-68 DOI: https://doi.org/10.1097/00054725-200403000-00015

Salzman NH, Polin RA, Harris MC, et al. Enteric defensin expression in necrotizing enterocolitis. Pediatr Res. 1998;44(1):20-6. DOI: https://doi.org/10.1203/00006450-199807000-00003

Neish AS, Gewirtz AT, Zeng H, et al. Pro-karyotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination. Science. 2000;289(5484):1560-3. DOI: https://doi.org/10.1126/science.289.5484.1560

Claud EC, Savidge T, Walker WA. Modu-lation of human intestinal epithelial cell IL-8 secretion by human milk factors. Pediatr Res. 2003;53(3):419-25. DOI: https://doi.org/10.1203/01.PDR.0000050141.73528.AD

Neish AS. Bacterial inhibition of eukary-otic pro-inflammatory pathways. Immunol Res. 2004;29(1-3):175-86. DOI: https://doi.org/10.1385/IR:29:1-3:175

Braga TD, da Silva GA, de Lira PI, et al. Efficacy of Bifidobacterium breve and Lactobacillus casei oral supplementation on necrotizing enterocolitis in very-low-birth-weight preterm infants: a double-blind, ran-domized, controlled trial. Am J Clin Nutr. 2011;93(1):81-6. DOI: https://doi.org/10.3945/ajcn.2010.29799

Garland SM, Tobin JM, Pirotta M, et al. The ProPrems trial:investigating the effects of probiotics on late onset sepsis in very preterm infants. BMC In-fect Dis. 2011;11:210. DOI: https://doi.org/10.1186/1471-2334-11-210

Deshpande G, Rao S, Patole S, et al. Up-dated meta-analysis of probiotics for prevent-ing necrotizing enterocolitis in preterm neo-nates. Pediatrics. 2010;125(5):921-30. DOI: https://doi.org/10.1542/peds.2009-1301

Alfaleh K, Anabrees J, Bassler D, et al. Probiotics for prevention of necrotizing en-terocolitis in preterm infants. Cochrane Data-base Syst Rev. 2011;(3):CD005496. DOI: https://doi.org/10.1002/14651858.CD005496.pub3

Tarnow-Mordi WO, Wilkinson D, Trivedi A, et al. Probiotics reduce all-cause mortality and necrotizing enterocolitis: it is time to change practice. Pediatrics. 2010;125(5):1068-70. DOI: https://doi.org/10.1542/peds.2009-2151

Deshpande GC, Rao SC, Keil AD, et al, Evidence-based guidelines for use of probiotics in preterm neonates. BMC Med. 2011;9:92 DOI: https://doi.org/10.1186/1741-7015-9-92

Neu J, Shuster J. Nonadministration of routine probiotics unethical--really? Pediat-rics. 2010;126(3):e740-1. DOI: https://doi.org/10.1542/peds.2010-1949A