Acute myeloid leukemia presented in the form of bullous pyoderma gangrenosum. A case report
DOI:
https://doi.org/10.51987/revhospitalbaires.v41i1.64Keywords:
pioderma gangrenoso ampollar, dermatosis neutrofílica, síndrome paraneoplásico, síndrome mielodisplásico, informe de caso, bullous pyoderma gangrenosum, neutrophilic dermatosis, paraneoplastic syndrome, myelodysplastic syndrome, case reportAbstract
Bullous pyoderma gangrenosum is an infrequent type of pyoderma gangrenosum, associated with onco hematological diseases in 50-70% of cases. We present the case of a 59-year-old patient with fever and mucocutaneous hemorrhagic bullous of rapid progression. A biopsy for histopathology, direct immunofluorescence (DIF) and skin culture was made, considering the possibility of neutrophilic dermatoses, bullous dermatosis or an opportunistic infection. The results of both the culture and the DIF were negative. The histopathological examination of the specimen revealed a dense dermal polymorphic infiltrate composed primarily of neutrophils. Considering bullous pyoderma gangrenosum as a potential diagnosis, a bone-marrow biopsy was performed. This study revealed an acute myeloid leukemia. Although systemic corticosteroid therapy was begun, the patient presented an unfavorable evolution that led to her death 15 days after her admission at the hospital.
This case shows the association between bullous pyoderma gangrenosum and onco hematological diseases. In addition, it highlights the poor prognosis related to these diseases in the short term.
Key words: bullous pyoderma gangrenosum, neutrophilic dermatosis, paraneoplastic syndrome, myelodysplastic syndrome, case report.
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