Response to “Genetic diagnosis and prophylactic surgery, an ethical challenge” written by Dr. Rosa A. Pace, in relation to an article I authored on genetic diagnosis of familial medullary thyroid carcinoma.

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Patricia Fainstein Day

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Fainstein Day P. Response to “Genetic diagnosis and prophylactic surgery, an ethical challenge” written by Dr. Rosa A. Pace, in relation to an article I authored on genetic diagnosis of familial medullary thyroid carcinoma. Rev Hosp Ital B.Aires [Internet]. 2005 Jun. 10 [cited 2026 Apr. 27];25(1):4-5. Available from: https://ojs.hospitalitaliano.org.ar/index.php/revistahi/article/view/1264

References

Pace RA. Diagnóstico genético y cirugía profiláctica, un desafío éti-co. Rev. Hosp. Ital. B.Aires 2004; 24: 46-47. DOI: https://doi.org/10.51987/Rev.Hosp.Ital.B.Aires.v24i2.1211

Fernández Gianotti T, Fainstein Day P, Russo Picasso MF y col. Carcinoma medular de tiroides familiar (CMTF): primera familia descriptacon CMTF asociado a la mutación Cys611Trp del proto-oncogen RET.Rev. Hosp. Ital. B.Aires 2004; 24: 8-11

Brandi ML, Gagel RF, Angeli A y col. Guidelines for diagnosis andtherapy of MEN type 1 and type 2. J Clin Endocrinol Metab 2001; 86:5658-71 DOI: https://doi.org/10.1210/jc.86.12.5658

Melvin KEW, Miller HH, Tashijian AH Jr. Early diagnosis of medullarycarcinoma of the thyroid gland by means of calcitonin assay. N Engl JMed 1971; 285: 1115-20 DOI: https://doi.org/10.1056/NEJM197111112852004

Wolfe HJ, Melvin KEW, Cervi-Skinner SJ y col. C-cell hyperplasiapreceding medullary thyroid carcinoma. N Engl J Med 1973; 289: 437-41 DOI: https://doi.org/10.1056/NEJM197308302890901

Graze K, Spiler IJ, Tashijan AH Jr y col. Natural history of familialmedullary thyroid carcinoma: effect of a program for early diagnosis. NEngl J Med 1978; 299: 980-5 DOI: https://doi.org/10.1056/NEJM197811022991804

Gagel RF, Tashijian AH Jr, Cummings T y col. The clinics outcome ofprospective screening for multiple endocrine neoplasia type 2a: a 18 yearexperience. N Engl J Med 1988; 318: 478-84 DOI: https://doi.org/10.1056/NEJM198802253180804

Mulligan LM,Kwork JB, Healey CS. Germ-line mutations of the RETproto-oncogen in multiple endocrine neoplasia type 2A. Nature 1993;363: 458-60. DOI: https://doi.org/10.1038/363458a0

Donnis Keller H, Dou S, Chi D y col. Mutations in the Ret proto-oncogen are associated with MEN 2A and FMTC. Hum Mol Genet 1993;2: 851-6. DOI: https://doi.org/10.1093/hmg/2.7.851

Wells SA Jr, Chi DD, Toshima K y col. Predictive DNA testing andprophylactic thyroidectomy in patients at risk for multiple endocrineneoplasia type 2A. Ann Surg 1994; 220: 237-50 DOI: https://doi.org/10.1097/00000658-199409000-00002

Lips CJM, Landsvater RM, Hoppener JW y col. Clinical screeningas compared with DNA analysis in families with multiple endocrine neo-plasia type 2A. N Engl J Med 1994; 331: 828-35. DOI: https://doi.org/10.1056/NEJM199409293311302

Machens A, Niccoli-Sire P, Hoegel J, et al. Early malignantprogression of hereditary medullary thyroid cancer. N Engl J Med 2003;349: 1517-25 DOI: https://doi.org/10.1056/NEJMoa012915