A case report of localized amyloidosis

Abstract

Localized amyloidosis is the term used for amyloid deposits in the local tissues, such as the tracheobronchial tree, urinary tract and skin. These deposits are derived from monoclonal light chains. Patients with localized amyloidosis do not develop systemic disease. This is a case of a 40- year-old who presented with progressive hoarseness for 8 months. The scan showed subglottic asymmetry on the left side compromising the light, without compromise of adjacent bony structures or lymphoid groups. Laryngoscopy was performed showing a stenotic lesion that compresses the vocal cords larynx with a mass of exophytic growth. Motility was preserved. It also showed a reduced glottal light of approximately 50%. Pathological examination revealed the presence of amyloid deposits. Additional studies were performed that discarded systemic involvement. Laryngeal amyloidosis is rare, however, it should be considered in the differential diagnosis of patients with laryngeal dysfunction. Localized amyloidosis does not require chemotherapy. The treatment of choice remains as conservative surgical resection