Therapeutic challenges in graft versus host disease
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Abstract
Graft versus host disease is an entity in which competent grafted immune cells recognize and damage tissue antigens present in the transplant recipient, who is unable to defend from them. It is one of the most serious complications in patients undergoing allogeneic bone marrow transplantation, although less frequently it may be associated with solid organ transplants or transfusions of not irradiated blood products. We report the case of a 23 year-old patient with acute lymphoblastic leukemia and allogeneic bone marrow transplantation, that presented graft versus host disease with skin and gastrointestinal involvement, dependent on corticosteroids, that showed improvement in signs and skin symptoms after treatment with infliximab and extracorporeal photopheresis
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Galimberti R, Carbajosa A, Subizar D, et al. Enfermedad injerto contra huésped. Piel. 2005; 20:443-5. DOI: https://doi.org/10.1016/S0213-9251(05)72323-6
Villafañe MJ, Moreno LH. Enfermedad injerto contra huésped. Dermatol Perú. 2012; 22:161-70.
Beirana A, Alcalá Pérez D, Franco Castro A. Enfermedad injerto contra huésped. Rev Cent Dermatol Pascua. 2000; 9: 74-80.
Brufau C, Fernández G, Vallejo JC. Enfermedad injerto contra huésped en el trasplante hematopoyético. Piel 2004;19:431-41. DOI: https://doi.org/10.1016/S0213-9251(04)72884-1
Dignan FL, Clark A, Amrolia P, et al. Diagnosis and management of acute graft-versus-host disease. Br J Haematol. 2012;158(1):30-45. DOI: https://doi.org/10.1111/j.1365-2141.2012.09129.x
Enz PA, De Luca DA, Galimberti RL. Enfermedad injerto contra huésped crónica y fotoféresis extracorpórea: comunicación de cinco casos. Dermatol Argent. 2013; 19(5):341-46.
Filipovich AH, Weisdorf D, Pavletic S, et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant. 2005;11(12):945-56. DOI: https://doi.org/10.1016/j.bbmt.2005.10.001
Knobler R, Berlin G, Calzavara-Pinton P, et al. Guidelines on the use of extracorporeal photopheresis. J Eur Acad Dermatol Venereol. 2014;28 Suppl 1:1-37. DOI: https://doi.org/10.1111/jdv.12311
Scarisbrick JJ, Taylor P, Holtick U, et al. U.K. consensus statement on the use of extracorporeal photopheresis for treatment of cutaneous T-cell lymphoma and chronic graft-versus-host disease. Br J Dermatol. 2008;158(4):659-78. DOI: https://doi.org/10.1111/j.1365-2133.2007.08415.x
García H, Velásquez E, Magaña MC, et al. Enfermedad injerto contra huésped. Rev Mex. 2006; 50:174-84.
Johnson ML, Farmer ER. Graft-versus-host reactions in dermatology. J Am Acad Dermatol. 1998;38(3):369-92; quiz 393-6. DOI: https://doi.org/10.1016/S0190-9622(98)70495-5
Rowlings PA, Przepiorka D, Klein JP, et al. IBMTR Severity Index for grading acute graft-versus-host disease: retrospective comparison with Glucksberg grade. Br J Haematol. 1997;97(4):855-64. DOI: https://doi.org/10.1046/j.1365-2141.1997.1112925.x